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Antiphospholipid antibodies associated with retinal vascular disease
J S Pulido1, L M Ward, G A Fishman
1Department of Ophthalmology, Eye and Ear Infirmary, University of Illinois College of Medicine, Chicago 60612.
Retina (Philadelphia, Pa.)
|January 1, 1987
Summary
Antiphospholipid antibodies, linked to lupus anticoagulant and anticardiolipin antibodies, were found in two patients with retinal vascular disease. Further investigation into this association and potential low-dose aspirin therapy is recommended.
Area of Science:
- Ophthalmology
- Rheumatology
- Hematology
Background:
- Antiphospholipid antibodies are associated with an increased risk of thrombotic events.
- Retinal vascular occlusive disease can be a manifestation of systemic thrombotic disorders.
Observation:
- Two patients with retinal vascular disease presented with antiphospholipid antibodies.
- One patient experienced retinal arterial occlusions, while the other had a central retinal vein occlusion.
Findings:
- The presence of antiphospholipid antibodies (lupus anticoagulant or anticardiolipin antibodies) was noted in patients with retinal vascular occlusions.
- This suggests a potential link between antiphospholipid antibodies and retinal vascular disease.
Implications:
- Investigating the association between antiphospholipid antibodies and thrombotic vascular disease (retinal and cerebral) is warranted.
- Low-dose aspirin may be a valuable therapeutic option for managing thrombotic events in patients with antiphospholipid antibodies and retinal vascular disease.