Pannexins in Acute Kidney Injury

Related Experiment Video

Updated: Jan 23, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

40.8K

Nabin Poudel1, Mark D Okusa2

  • 1Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.

Nephron
|June 27, 2019
PubMed

Insights

Pannexin 1 (Panx1) channels, involved in inflammation, show promise for treating acute kidney injury (AKI). Targeting Panx1 in animal models reduced inflammation and pathology, suggesting its therapeutic potential for AKI.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Immunology

Background:

  • Acute kidney injury (AKI) is common in hospitalized patients, leading to severe outcomes with few treatment options.
  • Pannexin 1 (Panx1) channels facilitate ATP release and are key in inflammatory disease progression.
  • Panx1's role in inflammation suggests it as a potential therapeutic target for AKI.

Purpose of the Study:

  • To explore the potential of Pannexin 1 (Panx1) as a therapeutic target for acute kidney injury (AKI).
  • To review the role of Panx1 in inflammatory processes relevant to AKI pathology.

Main Methods:

  • Review of existing literature on Pannexin 1 function in inflammation.
  • Analysis of data from animal models targeting Panx1 (pharmacological inhibition and genetic deficiency).

Main Results:

  • Animal models with targeted Panx1 inhibition or deficiency demonstrated reduced inflammation and pathology.
  • Panx1's involvement in multiple inflammatory pathways was highlighted.

Conclusions:

  • Pannexin 1 (Panx1) is a promising therapeutic target for acute kidney injury (AKI).
  • Further research is required to elucidate Panx1 mechanisms in AKI and develop specific inhibitors.
Keywords:
ATPAcute kidney injuryAdenosineMitochondriaPannexinsPurinergic signaling

More Related Videos

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.2K
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish13:25

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

6.5K

Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
624
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
947
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
305
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
415
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
843
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
279