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Updated: Jan 23, 2026

Historical View and Physiology Demonstration at the NMJ of the Crayfish Opener Muscle
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Eye Opener in Stroke.

Hung Nguyen1, Jea Young Lee1, Paul R Sanberg1

  • 1From the Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa (H.N., J.Y.L., P.R.S., C.V.B.).

Stroke
|June 28, 2019
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) can repair mitochondrial dysfunction caused by retinal ischemia, a condition linked to vision loss in stroke patients. This study shows MSCs improve cell survival and mitochondrial function in models of retinal ischemia.

Keywords:
cell survivalendothelial cellsglucosemitochondrial dynamicsoxygen

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Regenerative Medicine

Background:

  • Retinal ischemia is a significant cause of vision loss in stroke patients.
  • Current treatments are limited due to incomplete understanding of retinal ischemia pathology.
  • Mitochondrial dysfunction is implicated in the progression of retinal ischemia.

Purpose of the Study:

  • Investigate the role of mitochondrial dysfunction in retinal ischemia.
  • Evaluate the potential of mesenchymal stem cells (MSCs) for mitochondrial repair in retinal ischemia.
  • Examine the therapeutic effects of MSCs on retinal cell survival and function.

Main Methods:

  • In vivo: Rats underwent middle cerebral artery occlusion, followed by intravenous MSCs or vehicle treatment. Blood flow and cellular degeneration were assessed.
  • In vitro: Retinal pigmented epithelium cells were subjected to oxygen-glucose deprivation (OGD) with or without MSCs coculture. Cell death and mitochondrial function were analyzed.
  • Mitochondrial function was evaluated using Seahorse analyzer and immunocytochemistry.

Main Results:

  • Middle cerebral artery occlusion led to reduced blood flow, mitochondrial dysfunction, and ganglion cell death in rats.
  • Intravenous MSCs treatment improved mitochondrial repair and ganglion cell survival at 14 days post-stroke.
  • In vitro, MSCs coculture restored mitochondrial respiration, network morphology, and dynamics in OGD-exposed retinal cells, reducing cell death.

Conclusions:

  • Retinal ischemia is strongly associated with mitochondrial dysfunction.
  • Mesenchymal stem cells demonstrate potential for repairing mitochondrial damage in retinal ischemia.
  • Stem cell-mediated mitochondrial repair offers a promising therapeutic strategy for vision impairment due to retinal ischemia.