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Updated: Jan 22, 2026
05:52
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
15.4K
[Adolescent with a schizophreniform disorder and recurrent 16p11.2 duplication]
Tijdschrift Voor Psychiatrie
|June 28, 2019
Summary
Genetic factors contribute to psychotic disorders. A 16p11.2 duplication, a known copy number variant (CNV), was identified in an adolescent with psychosis, highlighting its role in psychiatric conditions.
Area of Science:
- Genetics
- Psychiatry
- Neurodevelopmental Disorders
Background:
- Genetic factors are increasingly recognized as significant contributors to the etiology of psychotic disorders.
- Rare copy number variants (CNVs) are emerging as important risk factors for these conditions.
Observation:
- This study details a case of an adolescent experiencing two psychotic episodes during their developmental period.
- A specific genetic finding, a 16p11.2 duplication, was identified in the patient.
Findings:
- The 16p11.2 duplication is a recurrent CNV with established associations to diverse phenotypes.
- This CNV is linked to both somatic and psychiatric conditions, notably including psychosis and schizophrenia.
Implications:
- The identification of this CNV in an adolescent with psychosis underscores its clinical relevance.
- This finding contributes to understanding the genetic underpinnings of psychotic disorders and may inform future diagnostic or therapeutic strategies.
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