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Sensory testing in non-human primates.

S G Gilbert1

  • 1Toxicology Research Division, Health and Welfare Canada, Ottawa, Ontario.

Zentralblatt Fur Bakteriologie, Mikrobiologie Und Hygiene. Serie B, Umwelthygiene, Krankenhaushygiene, Arbeitshygiene, Praventive Medizin
|October 1, 1987
PubMed
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Non-human primate sensory testing reveals chemical toxicity. Studies show visual and somatosensory psychophysics can detect subtle effects from methyl mercury and acrylamide exposure.

Area of Science:

  • Neuroscience
  • Toxicology
  • Primate research

Background:

  • Chemicals can cause subtle sensory damage.
  • Non-human primates offer a model for studying sensory systems.
  • Psychophysical methods are sensitive tools for detecting sensory deficits.

Purpose of the Study:

  • To demonstrate the utility of sensory testing in non-human primates for detecting chemical toxicity.
  • To provide examples of visual and somatosensory psychophysics in toxicological studies.

Main Methods:

  • Spatial contrast sensitivity was measured in monkeys exposed to methyl mercury.
  • Vibration sensitivity was assessed in monkeys exposed to acrylamide.
  • Psychophysical techniques were employed to quantify sensory perception.

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Main Results:

  • Methyl mercury exposure affected visual spatial contrast sensitivity in monkeys.
  • Acrylamide exposure impaired vibration sensitivity in monkeys.
  • These findings highlight the sensitivity of primate sensory models.

Conclusions:

  • Sensory testing in non-human primates is a valuable method for identifying subtle chemical-induced sensory toxicity.
  • Visual and somatosensory psychophysics are effective approaches for toxicological assessment in primates.
  • This methodology aids in understanding the neurotoxic effects of environmental and industrial chemicals.