Related Experiment Video
Updated: Jan 22, 2026
10:40
Discovering Middle Ear Anatomy by Transcanal Endoscopic Ear Surgery: A Dissection Manual
Published on: January 11, 2018
68.9K
Inner Ear Therapeutics: An Overview of Middle Ear Delivery
Jaimin Patel1, Mikhaylo Szczupak1, Suhrud Rajguru1,2
1Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United States.
Frontiers in Cellular Neuroscience
|June 28, 2019
Summary
This review explores innovative middle ear treatments for inner ear conditions. It covers current and historical therapies, focusing on drug delivery and novel approaches like hypothermia for inner ear damage.
Area of Science:
- Otolaryngology
- Drug Delivery Systems
- Regenerative Medicine
Background:
- The middle ear serves as a crucial portal for accessing the inner ear.
- Various therapeutic strategies utilize the middle ear for drug delivery and direct access to inner ear structures.
- Understanding middle ear dynamics is essential for effective inner ear treatments.
Purpose of the Study:
- To examine cutting-edge approaches for treating the middle ear.
- To review past and current therapies delivered via the middle ear.
- To provide a basis for understanding middle ear drug delivery and novel inner ear treatments.
Main Methods:
- Review of existing literature on middle ear access and therapies.
- Analysis of drug delivery systems utilizing the middle ear.
- Examination of novel therapeutic modalities, including hypothermia.
Main Results:
- The middle ear offers versatile applications in therapeutic interventions for the inner ear.
- Established and emerging methods for inner ear access through the middle ear are detailed.
- Hypothermia is presented as a novel approach to modulate inner ear responses to injury.
Conclusions:
- The middle ear is a key anatomical site for delivering therapies to the inner ear.
- Innovative treatments, including drug delivery via cochlear implants and hypothermia, show promise.
- Further research into middle ear-based therapies can advance inner ear treatment strategies.
Related Concept Videos
01:16Anatomy of the Ear
11.3K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
11.3K
01:16Drug Delivery: Overview
753
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
753
01:16Therapeutic Drug Monitoring: Overview and Classification
322
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
322
01:13Therapeutic Index
6.7K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.7K
01:30Therapeutic Communication
7.7K
Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
7.7K
01:29Microorganisms in Medicine and Therapeutics
1.0K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.0K