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Related Concept Videos

Conjugated Proteins02:50

Conjugated Proteins

27.5K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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Conjugated Proteins02:50

Conjugated Proteins

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Conjugation01:19

Conjugation

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Conjugation is a form of horizontal gene transfer that primarily occurs in bacteria and some archaea, promoting genetic diversity and adaptation. Bacteria can acquire resistance genes through conjugative plasmids, allowing them to survive antibiotic treatments that would otherwise be lethal. This process involves direct contact between cells through specialized structures such as the sex pilus and is mediated by conjugative plasmids, including the F (fertility) factor.Conjugation requires...
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Mechanism of Conjugation01:19

Mechanism of Conjugation

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Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
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Structure of Conjugated Dienes01:16

Structure of Conjugated Dienes

6.9K
Introduction
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...
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Stability of Conjugated Dienes01:28

Stability of Conjugated Dienes

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Introduction
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
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Related Experiment Video

Updated: Jan 22, 2026

Conjugative Mating Assays for Sequence-specific Analysis of Transfer Proteins Involved in Bacterial Conjugation
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Conjugative Mating Assays for Sequence-specific Analysis of Transfer Proteins Involved in Bacterial Conjugation

Published on: January 4, 2017

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DNA-supramolecule conjugates in theranostics.

Kun Chen1, Ting Fu1, Weidi Sun1

  • 1Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.

Theranostics
|June 28, 2019
PubMed
Summary

DNA-supramolecule conjugates (DSCs) merge DNA's precision with supramolecular chemistry's versatility. These advanced materials show promise in cancer diagnostics, therapy, and various biomedical applications.

Keywords:
DNA nanotechnologyDNA-supramolecule conjugateaptamerhost-guest interactionsupramolecular chemistry

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Area of Science:

  • Biomolecular Chemistry
  • Supramolecular Chemistry
  • Nanotechnology

Background:

  • Deoxyribonucleic acid (DNA) offers unique properties like recognition, programmability, and addressability for molecular tools.
  • Supramolecular chemistry focuses on assembling molecules via noncovalent forces for functional systems.

Purpose of the Study:

  • To review the applications of DNA-supramolecule conjugates (DSCs).
  • To highlight the synergistic combination of DNA and supramolecular chemistry principles.

Main Methods:

  • Literature review of DSCs in various scientific domains.
  • Analysis of DSCs' properties and applications.

Main Results:

  • DSCs leverage DNA's characteristics with supramolecular chemistry's broader scope.
  • DSCs demonstrate potential in sensing, regulating protein activity, and manipulating cell behavior.

Conclusions:

  • DSCs represent a powerful platform for advanced biomedical applications.
  • The integration of DNA and supramolecular chemistry opens new avenues in theranostics and beyond.