Protein Delivery into the Cell Cytosol using Non-Viral Nanocarriers
Yi-Wei Lee1, David C Luther1, Jessica A Kretzmann1,2
1Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, USA.
Abstract:
Protein delivery into cells is a potentially transformative tool for treating "undruggable" targets in diseases associated with protein deficiencies or mutations. The vast majority of these targets are accessed via the cytosol, a challenging prospect for proteins with therapeutic and diagnostic relevance. In this review we will present promising non-viral approaches for intracellular and ultimately cytosolic delivery of proteins using nanocarriers. We will also discuss the mechanistic properties that govern the efficacy of nanocarrier-mediated protein delivery, applications of nanomaterials, and key challenges and opportunities in the use of nanocarriers for intracellular protein delivery.
More Related Videos
11:53Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
Published on: July 21, 2017
11:12Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
Published on: March 9, 2013
Related Concept Videos
Viral Structure
Viral Recombination
Viral Mutations
Size and Structure of Viral Genomes
Viral Replication: Lytic Cycle
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme...
