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Updated: Jan 22, 2026

Measurement of Chitinase Activity in Biological Samples
Published on: August 22, 2019
Structures and biological activities of cycloheptamycins A and B
Zhengyi Qian1, Janine Antosch1, Jutta Wiese2
1Biosystems Chemistry, Department of Chemistry and Center for Integrated Protein Sciences Munich, Technical University of Munich, Lichtenbergstraße 4, 85748 Garching, Germany.
Abstract:
The heptadepsipeptide cycloheptamycin A was isolated from the terrestrial Streptomyces sp. Tü 6314. Its constitution was elucidated on the basis of NMR spectroscopic experiments and mass spectrometric analysis. Its stereostructure was investigated by peptide hydrolysis and derivatization and firmly established by X-ray structure analysis. In addition to the parent compound, a new cycloheptamycin analog, cycloheptamycin B, was discovered and structurally assigned using comparative MS/MS experiments and NMR. The biological profile of both compounds was investigated, revealing a selective inhibitory potential of cycloheptamycins against Propionibacterium acnes.
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