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A Solid-State Protein Junction Serves as a Bias-Induced Current Switch.

Jerry A Fereiro1, Ben Kayser1, Carlos Romero-Muñiz2

  • 1Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot, Israel.

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|June 28, 2019
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Summary
This summary is machine-generated.

This study demonstrates that a protein monolayer, using cytochrome C, can act as an electrically controlled switch. This breakthrough paves the way for novel protein-based bioelectronic devices.

Keywords:
bioelectronic junctionelectron transferon-off switchingresonant tunneling

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Area of Science:

  • Molecular electronics
  • Bio-nanotechnology
  • Protein engineering

Background:

  • Protein monolayers offer potential for novel electronic devices.
  • Controlling protein electronic properties requires understanding electrode-protein interfaces.

Purpose of the Study:

  • To investigate the feasibility of using cytochrome C as an electrically driven switch.
  • To explore the electronic coupling between cytochrome C and solid-state electrodes.

Main Methods:

  • Utilized *ab initio* DFT calculations to model cytochrome C-gold (Au) structures.
  • Fabricated and tested gold-cytochrome C-gold junctions using a cytochrome C mutant with S-Au bonding.
  • Measured electrical conductance under varying bias voltages up to room temperature.

Main Results:

  • DFT calculations revealed weak heme-electrode coupling, preventing Fermi level pinning.
  • Approximately 80% of fabricated junctions exhibited a clear conductance peak at >0.5 V bias, indicative of resonant tunneling.
  • Reversible on-off switching behavior was observed up to room temperature.

Conclusions:

  • Cytochrome C can function as a bias-controlled switch in a protein monolayer.
  • The observed switching mechanism is consistent with resonant tunneling through protein orbitals.
  • Protein ensembles offer a viable route to robust bioelectronics due to built-in redundancy.