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Published on: January 19, 2024
Anemia at Discharge From the PICU: A Bicenter Descriptive Study
Pierre Demaret1,2, Frédéric V Valla3, Hélène Behal4
1Division of Pediatric Critical Care Medicine, Department of Pediatrics, CHC, Liège, Belgium.
Insights
Anemia is common in children leaving the pediatric intensive care unit (PICU). Anemia at PICU admission is a key predictor of discharge anemia, with specific risk factors varying by age.
Area of Science:
- Pediatric critical care medicine
- Hematology
- Epidemiology
Background:
- Anemia is a frequent complication in critically ill children.
- Understanding anemia prevalence and risk factors at pediatric intensive care unit (PICU) discharge is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of anemia at PICU discharge.
- To identify risk markers associated with anemia at PICU discharge in children.
Main Methods:
- A bicenter retrospective cohort study was conducted.
- Data from 3,170 children admitted to two French PICUs over five years were analyzed.
- Anemia was defined using World Health Organization criteria.
Main Results:
- 58.9% of children were anemic at PICU discharge.
- Anemia at PICU admission was the strongest predictor of discharge anemia, with age-dependent associations.
- Factors influencing anemia risk included red blood cell transfusions, age, creatinine levels, platelet count, C-reactive protein, plasma transfusions, and mechanical ventilation.
Conclusions:
- Anemia is prevalent upon discharge from the PICU.
- Anemia status at PICU admission helps stratify risk for discharge anemia.
- Further research is needed to elucidate the causes and outcomes of post-PICU anemia.
Objective:
To determine the prevalence and risk markers of anemia at PICU discharge.
Design:
Bicenter retrospective cohort study.
Setting:
Two multidisciplinary French PICUs.
Patients:
All children admitted during a 5-year period, staying in the PICU for at least 2 days, and for whom a hemoglobin was available at PICU discharge.
Interventions:
None.
Measurements And Main Results:
Patient, admission, and PICU stay characteristics were retrospectively collected in the electronic medical records of each participating PICU. Anemia was defined according to the World Health Organization criteria. Among the 3,170 patients included for analysis, 1,868 (58.9%) were anemic at discharge from PICU. The proportion of anemic children differed between age categories, whereas the median hemoglobin level did not exhibit significant variations according to age. After multivariate adjustment, anemia at PICU admission was the strongest predictor of anemia at PICU discharge, and the strength of this association varied according to age (interaction). Children anemic at PICU admission had a reduced risk of anemia at PICU discharge if transfused with RBCs during the PICU stay, if less than 6 months old, or if creatinine level at PICU admission was low. Children not anemic at PICU admission had an increased risk of anemia at PICU discharge if they were thrombocytopenic at PICU admission, if they had higher C-reactive protein levels, and if they received plasma transfusion, inotropic/vasopressor support, or mechanical ventilation during the PICU stay.
Conclusions:
Anemia is frequent after pediatric critical illness. Anemia status at PICU admission defines different subgroups of critically ill children with specific prevalence and risk markers of anemia at PICU discharge. Further studies are required to confirm our results, to better define anemia during pediatric critical illness, and to highlight the causes of post-PICU stay anemia, its course, and its association with post-PICU outcomes.
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