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Related Experiment Videos

Computed tomography: pathologic correlation in lung disease due to tocainide.

M G Stein1, T Demarco, G Gamsu

  • 1Department of Radiology, University of California, San Francisco 94143.

The American Review of Respiratory Disease
|February 1, 1988
PubMed
Summary
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High resolution computed tomography (CT) effectively visualized tocainide-induced lung injury, revealing both alveolar and interstitial abnormalities. This imaging technique correlated with biopsy results, confirming its utility in diagnosing drug-induced pulmonary toxicity.

Area of Science:

  • Pulmonology
  • Radiology
  • Toxicology

Background:

  • Drug-induced lung diseases are a significant clinical concern.
  • Tocainide, an antiarrhythmic drug, can cause pulmonary toxicity.
  • Accurate diagnosis of drug-induced lung injury is crucial for patient management.

Observation:

  • A patient presented with suspected tocainide pulmonary toxicity.
  • High-resolution computed tomography (CT) was employed to image the lungs.
  • Gallium uptake indicated active lung inflammation.

Findings:

  • High-resolution CT revealed both interstitial and alveolar components of lung abnormality.
  • Transbronchial biopsy confirmed interstitial pneumonitis with alveolar macrophages.
  • Discontinuation of tocainide led to reversal of the pulmonary process.

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Implications:

  • High-resolution CT is a valuable tool for diagnosing fine lung morphology changes in drug-induced pulmonary toxicity.
  • CT findings correlate well with pathological examination.
  • Early identification and drug cessation can lead to favorable outcomes in drug-induced lung disease.