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Updated: Jan 22, 2026

HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin
Published on: July 23, 2016
Three-Component Synthesis of Isoquinoline Derivatives by a Relay Catalysis with a Single Rhodium(III) Catalyst
Chao Zhou1, Jijun Jiang1, Jun Wang1
1Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry , Sun Yat-Sen University , Guangzhou 510275 , P. R. China.
Abstract:
A rhodium(III)-catalyzed one-pot three-component reaction of N-methoxybenzamide, α-diazoester, and alkyne was developed, providing an alternative way to synthesize isoquinoline derivatives. Mechanistically, it is a relay catalysis, and the reaction occurred via successive O-alkylation and C-H activation processes, both of which were promoted by the same catalyst.
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