HCN on Tap: On-Demand Continuous Production of Anhydrous HCN for Organic Synthesis
Manuel Köckinger1,2, Christopher A Hone1,2, C Oliver Kappe1,2
1Center for Continuous Flow Synthesis and Processing (CCFLOW) , Research Center Pharmaceutical Engineering GmbH (RCPE) , Inffeldgasse 13 , 8010 Graz , Austria.
Abstract:
A continuous process for the on-demand generation, separation, and reaction of hydrogen cyanide (HCN) using membrane separation technology was developed. The inner tube of the reactor is manufactured from a gas-permeable, hydrophobic fluoropolymer (Teflon AF-2400) membrane. HCN is formed from aqueous reagents within the inner tube and then diffuses through the membrane into an outer tubing containing organic solvent. This technique enabled the safe handling of HCN for three different organic transformations without the need for distillation.
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