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Updated: Jan 22, 2026

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes
Published on: November 21, 2017
Ni/Photoredox-Dual-Catalyzed Functionalization of 1-Thiosugars
Mingxiang Zhu1, Guillaume Dagousset2, Mouad Alami1
1BioCIS , Université Paris-Sud, CNRS, University Paris-Saclay , Châtenay-Malabry , France.
Abstract:
A general protocol for functionalization of glycosyl thiols has been reported. This protocol is based on a single-electron Ni/photoredox dual-catalyzed cross coupling between 1-thiosugars and a broad range of aryl bromides and iodides as well as alkenyl and alkynyl halides. This base-free method gives access to a series of functionalized thioglycosides in moderate to excellent yields with a perfect control of the anomeric configuration. Moreover, it has been shown that this methodology may be transposed successfully to the continuous-flow photoredox chemistry.
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