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Pentafluoroethyl Sulfoximine Reagent for the Photocatalytic Pentafluoroethylation-Difunctionalization of Styrene
Lu Lin1, Gabriel Goujon2, Bruce Pégot2
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR 999077, China.
Abstract:
We herein describe the synthesis of a pentafluoroethyl sulfoximine and its application in the pentafluoroethylation-difunctionalization of styrene derivatives. This sulfoximine reagent acts as a source of pentafluoroethyl radical to react with styrenes under mild photocatalytic conditions. By using simple nucleophiles, the pentafluoroethyl group can be introduced to styrenes with concomitant formation of C-O/C-N/C-S/C-C bonds, which significantly broadens the difunctionalization scope involving pentafluoroethylation compared to previous copper-based methods.
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