Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Social Traps01:41

Social Traps

26.3K
Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
26.3K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

14.6K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.6K
What are Cells?01:07

What are Cells?

197.6K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
197.6K
Voltaic/Galvanic Cells02:47

Voltaic/Galvanic Cells

63.1K
Spontaneous Chemical Reactions
Spontaneous redox reactions occur abundantly in nature. The chemical reaction occurring in a disposable AA battery powering our remote controls is one such example of a spontaneous redox reaction. Another example is the immersion of coiled copper wire into an aqueous silver nitrate solution. The reaction shows a gradual, visually impressive color change from colorless to bright blue and the formation of a grey precipitate on the copper wire. In this experiment,...
63.1K
Concentration Cells02:41

Concentration Cells

25.6K
A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
25.6K
Batteries and Fuel Cells03:12

Batteries and Fuel Cells

30.8K
A battery is a galvanic cell that is used as a source of electrical power for specific applications. Modern batteries exist in a multitude of forms to accommodate various applications, from tiny button batteries such as those that power wristwatches to the very large batteries used to supply backup energy to municipal power grids. Some batteries are designed for single-use applications and cannot be recharged (primary cells), while others are based on conveniently reversible cell reactions that...
30.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fine-Mapping-Based Variant Prioritization and Genomic Prediction Enhance Genetic Analyses of Teat Traits in Pigs.

Animals : an open access journal from MDPI·2026
Same author

Quantifying Lattice Strains in Elastically Deformed Covalent Crystals.

Physical review letters·2026
Same author

Resolving intrinsic dislocation structure in perovskite crystals using pulsed electron beam with atomic resolution.

Nature communications·2026
Same author

Distinct Roles of Internal Cavity Volume and Shape in Modulating Thermostability and Catalytic Activity of Microbial Transglutaminase.

Journal of agricultural and food chemistry·2026
Same author

TKOA-GPNN: a model framework for genotype-to-phenotype prediction in Duroc pigs.

BMC genomics·2026
Same author

Flexural phonon instability defines intrinsic van der Waals elastic limits in the interlayer direction.

Nature communications·2026
Same journal

Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

Micromachines·2026
Same journal

Femtosecond Laser Texturing of Wood Coatings with Bio-Based Epoxy and Wax Additives for Enhanced Hydrophobicity.

Micromachines·2026
Same journal

Engineering of Optoelectronic Devices for Renewable Energy Applications.

Micromachines·2026
Same journal

Phase Transformation and Electrochemical Behavior of Hexagonal TiO<sub>2</sub> Nanotubes Under Different Annealing Temperatures and Heating Rates.

Micromachines·2026
Same journal

Process Optimization and Predictive Modeling of Femtosecond Laser Precision Milling for Commercial PMMA Slices.

Micromachines·2026
Same journal

A Hybrid Preprocessing Multi-Objective Surrogate Model for Thermal MEMS Actuators.

Micromachines·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

A Microfluidic-based Hydrodynamic Trap for Single Particles
10:13

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

17.2K

Microfluidic Cell Trapping for Single-Cell Analysis.

Bing Deng1, Heyi Wang2, Zhaoyi Tan3

  • 1Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215000, China. dengbing_48@163.com.

Micromachines
|June 29, 2019
PubMed
Summary
This summary is machine-generated.

A U-shaped microfluidic chip excels at single-cell capture, enabling long-term culture and observation. This fluid dynamics-based approach offers superior cell viability and analysis compared to other chip designs.

Keywords:
U-shapedcell trappingflow short cutmicrocavitymicrofluidic

More Related Videos

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

15.5K
Single-cell Microfluidic Analysis of Bacillus subtilis
10:37

Single-cell Microfluidic Analysis of Bacillus subtilis

Published on: January 26, 2018

12.6K

Related Experiment Videos

Last Updated: Jan 22, 2026

A Microfluidic-based Hydrodynamic Trap for Single Particles
10:13

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

17.2K
A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

15.5K
Single-cell Microfluidic Analysis of Bacillus subtilis
10:37

Single-cell Microfluidic Analysis of Bacillus subtilis

Published on: January 26, 2018

12.6K

Area of Science:

  • Biotechnology
  • Microfluidics
  • Cell Biology

Background:

  • Microfluidic chips offer advantages like low cost and high throughput for life science and pharmaceutical analysis.
  • Single-cell analysis promises detailed study of intracellular components.

Purpose of the Study:

  • To compare the cell capture efficiency of three different fluid dynamics-based microfluidic chip structures.
  • To evaluate the effects of different chip structures on cell growth, distribution, and subsequent analysis.

Main Methods:

  • Three microfluidic chip structures utilizing fluid dynamics for cell capture were designed and tested.
  • Cell capture efficiency, post-capture cell behavior (growth, distribution), and observation quality were assessed for each structure.

Main Results:

  • The U-shaped structure demonstrated superior single-cell capture, facilitating long-term culture and observation with high cell viability.
  • Microcavity structures led to cell overlap, hindering analysis, while flow shortcut structures caused cell deformation due to fluid shear forces.

Conclusions:

  • The U-shaped microfluidic chip is the most suitable design for single-cell capture, culture, and observation.
  • Findings provide theoretical support for designing advanced single-cell capture microfluidic chips and offer a reference for future research.