Related Experiment Video

Updated: Jan 22, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:12

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

1.4K

Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel

Costantino Iadecola1, Marco Duering2, Vladimir Hachinski3

  • 1Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York.

Journal of the American College of Cardiology
|June 29, 2019
PubMed

Insights

Vascular cognitive impairment and dementia (VCID) is a significant public health concern, particularly in East Asia. This review critically appraises VCID epidemiology, pathology, and treatment, highlighting research needs.

Area of Science:

  • Neurology
  • Public Health
  • Gerontology

Background:

  • Cognitive impairment in aging is a growing global challenge.
  • While Alzheimer's disease is common in the West, vascular cognitive impairment and dementia (VCID) is the second leading cause and may be predominant in East Asia.
  • Cerebral vascular changes, including microcirculation, significantly contribute to cognitive dysfunction, even in Alzheimer's disease.

Purpose of the Study:

  • To provide a critical review of vascular cognitive impairment and dementia (VCID).
  • To examine the epidemiology, pathobiology, neuropathology, and neuroimaging of VCID.
  • To assess current diagnostic and therapeutic strategies and identify research gaps.

Main Methods:

  • Expert panel review and critical appraisal of existing literature.
  • Synthesis of data on epidemiology, pathobiology, neuropathology, and neuroimaging.
  • Analysis of current diagnostic and therapeutic approaches.

Main Results:

  • Vascular factors are crucial in cognitive impairment, irrespective of underlying pathology like Alzheimer's disease.
  • VCID presents a significant challenge, with regional variations in prevalence (e.g., East Asia).
  • Current understanding highlights the need for integrated approaches considering both vascular and other pathologies.

Conclusions:

  • VCID is a major contributor to dementia, necessitating focused research and clinical attention.
  • Further research into epidemiology, pathobiology, and neuroimaging is essential for improved diagnostics and therapeutics.
  • Addressing unresolved issues in VCID research is critical for mitigating this devastating condition.

Keywords:
Alzheimer’s diseasecerebral blood flowcognitive dysfunctionsmall vessel diseasestroke

More Related Videos

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.7K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

Related Concept Videos

The Scientific Method03:50

The Scientific Method

Chemistry is an empirical science. Scientists often pose questions to understand the chemistry in everyday life and seek answers to these questions. To achieve this, scientists follow a definitive series of steps that together make up the Scientific Method. This approach involves making observations, asking questions, building a hypothesis, conducting experiments, analyzing results, and forming a conclusion. 
65.3K
The Scientific Method01:32

The Scientific Method

The scientific method is a detailed, empirical problem-solving process used by biologists and other scientists. This iterative approach involves formulating a question based on observation, developing a testable potential explanation for the observation (called a hypothesis), making and testing predictions based on the hypothesis, and using the findings to create new hypotheses and predictions.
Generally, predictions are tested using carefully-designed experiments. Based on the outcome of these...
260.2K
The Scientific Method02:40

The Scientific Method

Research is what makes the difference between facts and opinions. Facts are observable realities, and opinions are personal judgments, conclusions, or attitudes that may or may not be accurate. In the scientific community, facts can be established only using evidence collected through empirical research.
64.9K
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
534
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
36.8K
Scientific Laws and Theories02:31

Scientific Laws and Theories

Scientific Laws
87.5K