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Updated: Jan 22, 2026
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Robot-Assisted Kidney Transplantation
Published on: July 19, 2021
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ABO incompatible kidney transplantation: the Saudi experience
Tariq Ali1, Dieter Broering1, Hassan Aleid1
1Department of Kidney and Pancreas Transplant, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Summary
ABO-incompatible kidney transplants in Saudi Arabia showed excellent patient survival (100%) and high graft survival (94.8%) within the first year. The study observed low infectious complications, suggesting the immunosuppressive protocol is safe for these kidney transplant recipients.
Area of Science:
- Nephrology
- Transplantation Immunology
- Immunosuppression
Background:
- ABO-incompatible (ABOi) kidney transplantation offers a vital option for patients with end-stage renal disease.
- However, ABOi recipients face increased risks of antibody-mediated rejection (AMR) and infections, potentially impacting graft and patient survival.
- Outcomes in the Saudi population remain largely unknown.
Purpose of the Study:
- To evaluate patient and graft survival rates in ABO-incompatible kidney transplant recipients within the Saudi population.
- To assess the incidence of rejection, infectious complications, and overall safety of the established immunosuppressive protocol.
Main Methods:
- A retrospective analysis of 77 adult ABOi kidney transplant recipients between 2007 and 2016.
- Patients received a standardized desensitization protocol including rituximab, therapeutic plasma exchange, and thymoglobulin.
- Maintenance immunosuppression comprised prednisone, mycophenolate mofetil, and tacrolimus.
Main Results:
- One-year patient survival was 100%, with graft survival at 94.8%.
- Early AMR occurred in 7.8% of patients, and acute cellular rejection in 17%.
- Urinary tract infections were the most common complication (32.5%), with no severe viral or fungal infections reported.
Conclusions:
- The implemented immunosuppressive protocol demonstrates excellent patient and graft survival in Saudi ABOi kidney transplant recipients.
- The protocol is associated with a low risk of severe infectious complications, indicating its safety and efficacy.
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