Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

597
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
597
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

578
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
578
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

359
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
359
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

331
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
331
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

2.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.3K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.6K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adeno-Associated Virus Gene Therapy Translation: Lessons from Early Regulatory Meetings.

Human gene therapy·2026
Same author

Shape-Conserving Atom Replacements.

Chemical reviews·2026
Same author

Optimization of systemic AAV9 gene therapy in Niemann-Pick disease, type C1 mice.

Life science alliance·2026
Same author

Switchable and Selective Synthesis of Unsymmetrical <i>N</i>-Aryl Pyrazoles from 1,2,3-Thiadiazine <i>S</i>-Oxides.

Journal of the American Chemical Society·2026
Same author

Mapping metabolic dependences and capacities using ATP as a biomarker.

Research square·2025
Same author

β-III tubulin identifies anti-fibrotic state of pericytes in pulmonary fibrosis.

Research square·2025

Related Experiment Video

Updated: Jan 22, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Chronic kidney disease in propionic acidemia.

Oleg A Shchelochkov1, Irini Manoli1, Jennifer L Sloan1

  • 1National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Genetics in Medicine : Official Journal of the American College of Medical Genetics
|June 29, 2019
PubMed
Summary
This summary is machine-generated.

Chronic kidney disease (CKD) is common in adults with propionic acidemia (PA), showing an age-dependent decline. Standard eGFR equations may misdiagnose CKD in PA patients, delaying crucial management.

Keywords:
GFRchronic kidney diseasecreatininecystatin Cpropionic acidemia

More Related Videos

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.4K
A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
10:51

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys

Published on: December 2, 2014

11.5K

Related Experiment Videos

Last Updated: Jan 22, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.4K
A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
10:51

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys

Published on: December 2, 2014

11.5K

Area of Science:

  • Metabolic disorders
  • Nephrology
  • Genetics

Background:

  • Propionic acidemia (PA) is a severe inherited metabolic disorder.
  • PA leads to multiorgan pathology, including kidney disease.
  • The prevalence and risk factors for chronic kidney disease (CKD) in PA are largely unknown.

Purpose of the Study:

  • To determine the prevalence of CKD in propionic acidemia patients.
  • To identify factors associated with CKD in propionic acidemia.
  • To evaluate the accuracy of standard eGFR equations in PA patients.

Main Methods:

  • A cross-sectional analysis was performed on 31 PA subjects.
  • Data included laboratory and clinical evaluations from a natural history study (NCT02890342).
  • Creatinine-based estimated glomerular filtration rate (eGFR) was assessed.

Main Results:

  • Renal function showed an age-dependent decline in PA patients (P < 0.002).
  • 50% of adult PA patients had eGFR <60 mL/min/1.73 m².
  • Plasma lipocalin-2 and uric acid were strongly associated with CKD (P < 0.0001).

Conclusions:

  • CKD is prevalent in adults with PA and linked to age.
  • Standard eGFR equations exhibit poor predictive performance in PA.
  • Delayed CKD recognition and management may occur due to inaccurate eGFR estimations.