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Related Experiment Video

Updated: Jan 22, 2026

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

Published on: October 24, 2017

Medicines in pregnancy.

Sarah Je Stock¹, Jane E Norman^2,3

¹Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Nine Edinburgh BioQuarter, 9 Little France Road, Edinburgh, EH16 4UX, UK.

|June 29, 2019

Summary

This summary is machine-generated.

Medication use during pregnancy lacks safety data due to exclusion from trials. Increased investment and legislation are needed for safe drug development and use in pregnant women.

Keywords:

Child Health Maternal Health Medicines Newborn Health Pharmacokinetics Pharmacovigilance Pregnancy Public Health

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Area of Science:

Pharmacology
Obstetrics
Public Health

Background:

Medication use in pregnancy is common, yet significant knowledge gaps exist regarding drug safety, dosage, and long-term effects.
Pregnant women are often excluded from clinical trials, leading to a lack of pharmacokinetic and long-term outcome data for many treatments.
Existing treatments are frequently old, untested, or prescribed off-label without adequate safety information, posing risks to both mother and child.

Purpose of the Study:

To highlight the critical need for improved research and drug development concerning medication use in pregnancy.
To address the public health concern of inadequate investment in obstetric drug development and the lack of data on medication safety during pregnancy.

Main Methods:

This study is a review and analysis of the current state of research and investment in medication use during pregnancy.
It synthesizes existing literature on the exclusion of pregnant women from clinical trials and the consequences of this exclusion.
It identifies gaps in knowledge regarding pharmacokinetics, safety, and long-term outcomes of medications used by pregnant individuals.

Main Results:

There is a profound lack of investment in developing new medications for obstetric conditions.
Pregnant women's exclusion from clinical trials results in minimal information on drug safety, efficacy, and optimal dosing.
Current practices often involve using old, untested medications off-label, increasing risks.

Conclusions:

Urgent investment and legislative changes are required to include pregnant women in clinical studies.
There is a need to capture high-quality data on medication use in pregnancy and encourage the development of new medicinal products for obstetric conditions.
Addressing these issues is crucial for improving maternal and child health outcomes globally.