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Non-adenomatous inappropriate TSH hypersecretion and euthyroidism requires no treatment
I A Hughes1, K Ichikawa, L J Degroot
1Department of Child Health, University of Wales College of Medicine, Cardiff, UK.
Clinical Endocrinology
|October 1, 1987
Abstract:
The syndrome of inappropriate TSH secretion is described in a euthyroid girl and her father. Based on nuclear T3 binding studies in fibroblasts, generalized tissue resistance was associated with a lower binding affinity for T3 in nuclear extracts suggestive of a structurally abnormal receptor for T3. Early recognition of the syndrome and observation of the short-term response to thyroid medication prevented unnecessary trials of antithyroid medication and later radical ablative thyroid treatment.