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Does Pasteurized Donor Human Milk Efficiently Protect Preterm Infants Against Oxidative Stress?

Anna Parra-Llorca1, María Gormaz2, Ángel Sánchez-Illana1

  • 1Neonatal Research Group, Health Research Institute La Fe, Valencia, Spain.

Antioxidants & Redox Signaling
|June 29, 2019
PubMed

Insights

Pasteurized donor human milk (DHM) provides preterm infants with nutrition comparable to own mother's milk (OMM). This study found no significant difference in oxidative stress biomarkers between infants fed DHM versus OMM.

Area of Science:

  • Neonatology
  • Nutritional Science
  • Biochemistry

Background:

  • Pasteurized donor human milk (DHM) is crucial for infants lacking own mother's milk (OMM).
  • The impact of DHM on oxidative stress in preterm infants is not well understood.
  • Oxidative stress is a significant concern in preterm infant health.

Purpose of the Study:

  • To investigate whether DHM protects preterm infants from oxidative stress.
  • To compare oxidative stress levels in preterm infants fed DHM versus OMM.
  • To assess the longitudinal changes in oxidative stress biomarkers.

Main Methods:

  • Quantified urinary oxidative stress biomarkers in preterm infants (≤32 weeks gestation, ≤1500g birth weight).
  • Compared infants receiving ≥80% DHM versus OMM.
  • Utilized noninvasive in vivo assessment from full enteral nutrition to hospital discharge.

Main Results:

  • No statistically significant difference in urinary oxidative stress biomarkers between DHM and OMM groups.
  • Longitudinal assessment showed comparable oxidative stress levels over time.
  • This is the first longitudinal study comparing DHM and OMM for oxidative stress in preterm infants.

Conclusions:

  • Pasteurized donor human milk (DHM) is a viable alternative to own mother's milk (OMM) for preterm infants.
  • DHM appears to protect preterm infants from oxidative stress as effectively as OMM.
  • Further research could explore DHM's role in preventing oxidative stress-related diseases.

Keywords:
biomarkersdonor human milk (DHM)full enteral feedingown mother's milk (OMM)oxidative stresspreterm infant

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