Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stereotype Content Model02:16

Stereotype Content Model

15.4K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.4K
Measurement of Air Content in Concrete01:23

Measurement of Air Content in Concrete

607
Air content measurement in concrete is critical for ensuring structural integrity and durability of concrete structures, especially in environments prone to severe weather conditions. Accurate air content analysis optimizes concrete's resistance to freeze-thaw cycles and enhances its workability and strength. Several methods are standardized under ASTM guidelines to measure the air content in fresh concrete, each suitable for different concrete types and conditions.
The pressure method,...
607
Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

4.6K
Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
4.6K
Moisture Content and Bulking of Aggregate01:10

Moisture Content and Bulking of Aggregate

424
The moisture content of aggregates is a crucial factor in construction, particularly in concrete mixing, as it influences the total water required in the mix. Moisture content represents the water coated on the exterior surface of the aggregate existing in a saturated and surface-dry condition. The total water content of a moist aggregate is the sum of its moisture content and water absorption.
When aggregates are exposed to rain or sit in stockpiles, they absorb moisture, which must be...
424
Body Water Content and Fluid Compartments01:19

Body Water Content and Fluid Compartments

4.0K
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
4.0K
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

498
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
498

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The AML cellular state space unveils NPM1 immune evasion subtypes with distinct clinical outcomes.

Nature communications·2025
Same author

MALNC: a new mutant NPM1/IDH2<sup>R140</sup> and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response.

Cancer gene therapy·2025
Same author

The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia.

Leukemia·2023
Same author

An open chat with…Simon Rayner.

FEBS open bio·2022
Same author

Globally Accessible Distributed Data Sharing (GADDS): a decentralized FAIR platform to facilitate data sharing in the life sciences.

Bioinformatics (Oxford, England)·2022
Same author

The limits of human microRNA annotation have been met.

RNA (New York, N.Y.)·2022

Related Experiment Video

Updated: Jan 22, 2026

A Neuronal and Astrocyte Co-Culture Assay for High Content Analysis of Neurotoxicity
15:04

A Neuronal and Astrocyte Co-Culture Assay for High Content Analysis of Neurotoxicity

Published on: May 5, 2009

25.7K

miRBaseMiner, a tool for investigating miRBase content.

Xiangfu Zhong1, Fatima Heinicke1, Simon Rayner1

  • 1Department of Medical Genetics, Oslo University Hospital and University of Oslo , Oslo , Norway.

RNA Biology
|June 29, 2019
PubMed
Summary

miRBaseMiner is a new tool that helps researchers explore microRNA (miRNA) annotation data. It aids in understanding complex miRNA features and changes across miRBase releases for more accurate biological analysis.

Keywords:
MicrornaNGSannotationcharacterizationmiRBasemiRBaseMinermiRNA

More Related Videos

Using a Virtual Store As a Research Tool to Investigate Consumer In-store Behavior
09:17

Using a Virtual Store As a Research Tool to Investigate Consumer In-store Behavior

Published on: July 24, 2017

11.8K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

2.0K

Related Experiment Videos

Last Updated: Jan 22, 2026

A Neuronal and Astrocyte Co-Culture Assay for High Content Analysis of Neurotoxicity
15:04

A Neuronal and Astrocyte Co-Culture Assay for High Content Analysis of Neurotoxicity

Published on: May 5, 2009

25.7K
Using a Virtual Store As a Research Tool to Investigate Consumer In-store Behavior
09:17

Using a Virtual Store As a Research Tool to Investigate Consumer In-store Behavior

Published on: July 24, 2017

11.8K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

2.0K

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • microRNAs (miRNAs) are key regulators of gene expression.
  • miRBase is the primary reference for miRNA annotation and analysis.
  • The complexity and size of miRBase can hinder comprehensive user exploration.

Purpose of the Study:

  • To develop a software tool, miRBaseMiner, for investigating miRBase annotation.
  • To enable users to generate custom annotation sets for specific research needs.
  • To characterize changes and features across miRBase releases (v9.2 to v22).

Main Methods:

  • Development of the miRBaseMiner software tool.
  • Application of miRBaseMiner to analyze miRBase releases from v9.2 to v22.
  • Characterization of specific annotation features impacting data analysis.

Main Results:

  • miRBaseMiner facilitates exploration of miRBase annotation complexity.
  • Analysis revealed key annotation features to consider, including sequence similarity, multiple genome locations, low minimum free energy hairpin precursors, reverse complementarity, and 3' poly(A) ends.
  • Changes in annotation across miRBase releases were systematically examined.

Conclusions:

  • miRBaseMiner enhances the utility of miRBase for researchers.
  • Understanding specific annotation features is crucial for accurate interpretation of miRNA data.
  • The tool supports informed biological and clinical conclusions derived from miRNA studies.