Imaging Heart Dynamics With Ultrafast Cascaded-Wave Ultrasound

The heart is an organ with highly dynamic complexity, including cyclic fast electrical activation, muscle kinematics, and blood dynamics. Although ultrafast cardiac imaging techniques based on pulsed-wave ultrasound (PUS) have rapidly emerged to permit mapping of heart dynamics, they suffer from limited sonographic signal-to-noise ratio (SNR) and penetration due to insufficient energy delivery and inevitable attenuation through the chest wall. We hereby propose ultrafast cascaded-wave ultrasound (uCUS) imaging to depict heart dynamics in higher SNR and larger penetration than conventional ultrafast PUS. To solve the known tradeoff between the length of transmitted ultrasound signals and spatial resolution while achieving ultrafast frame rates (>1000 Hz), we develop a cascaded synthetic aperture (CaSA) imaging method. In CaSA, an array probe is divided into subapertures; each subaperture transmits a train of diverging waves. These diverging waves are weighted in both the aperture (i.e., spatial) and range (i.e., temporal) directions with a coding matrix containing only +1 and -1 polarity coefficients. A corresponding spatiotemporal decoding matrix is designed to recover backscattered signals. The decoded signals are thereafter beamformed and coherently compounded to obtain one high-SNR beamformed image frame. For CaSA with M subapertures and N cascaded diverging waves, sonographic SNR is increased by 10× log ₁₀ (N ×M) (dB) compared with conventional synthetic aperture (SA) imaging. The proposed uCUS with CaSA was evaluated with conventional SA and Hadamard-encoded SA (H-SA) methods in a calibration phantom for B-mode image quality and an in vivo human heart in a transthoracic setting for the quality assessment of anatomical, myocardial motion, and chamber blood power Doppler images. Our results demonstrated that the proposed uCUS with CaSA (4 subapertures, 32 cascaded waves) improved SNR (+20.46 dB versus SA, +14.83 dB versus H-SA) and contrast ratio (+8.44 dB versus SA, +7.81 dB versus H-SA) with comparable spatial resolutions to and at the same frame rates as benchmarks.