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Updated: Jan 22, 2026
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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
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Extra-Skeletal Effects of Vitamin D
Rose Marino1, Madhusmita Misra2
1Pediatric Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Nutrients
|June 30, 2019
Summary
Vitamin D deficiency
Area of Science:
- Endocrinology and Immunology
Background:
- Vitamin D receptor (VDR) is expressed in various non-bone cells, including immune cells and organs like the brain, heart, and gut.
- Vitamin D deficiency is linked to numerous conditions, including diabetes, autoimmune disorders, and cancer.
Purpose of the Study:
- To review the extra-skeletal effects of vitamin D deficiency.
- To focus on evidence from randomized controlled trials and meta-analyses.
Main Methods:
- Review of existing literature, focusing on randomized controlled trials (RCTs) and meta-analyses.
- Examination of epidemiological and case-control studies suggesting links between vitamin D deficiency and various diseases.
Main Results:
- Epidemiological studies often suggest associations between vitamin D deficiency and diseases like type 1 and type 2 diabetes, immune disorders, and cancer.
- Interventional studies, however, have largely failed to establish a causal link for these conditions.
Conclusions:
- While observational studies suggest a link between vitamin D deficiency and extra-skeletal diseases, robust interventional evidence is often lacking.
- Further research is needed to clarify the causative role of vitamin D in non-skeletal health outcomes.
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