Related Experiment Video
Updated: Jan 22, 2026

Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope
Published on: February 28, 2019
High-speed atomic force microscope with a combined tip-sample scanning architecture
1State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China.
A novel high-speed atomic force microscope (HS-AFM) achieves 100 Hz line rates using a tip-sample combined scanning architecture. This advanced HS-AFM design enhances dynamic performance and sample handling capabilities.
Area of Science:
- Surface Science
- Microscopy Technology
- Nanotechnology
Background:
- Atomic Force Microscopy (AFM) is crucial for nanoscale imaging.
- Conventional AFMs often face limitations in scanning speed and sample manipulation.
- High-speed imaging is essential for observing dynamic processes at the nanoscale.
Purpose of the Study:
- To develop and present a novel high-speed atomic force microscope (HS-AFM).
- To improve scanning speed and dynamic performance compared to existing AFM systems.
- To enable robust imaging of larger and heavier samples.
Main Methods:
- Implemented a tip-sample combined scanning architecture.
- Separated the X-scanner (sample stage) from the AFM head containing Y and Z scanners.
- Enhanced the optical beam deflection method for wide-range probe tracking.
- Utilized a novel probe holder for easy probe exchange and alignment.
Main Results:
- Achieved a line rate of up to 100 Hz using proportional-integral-derivative control and linear driving.
- Demonstrated improved dynamic performance and carrying capacity due to scanner separation.
- Confirmed the system's capability to handle samples up to several centimeters in size and over 40 g in mass.
Conclusions:
- The presented HS-AFM design significantly enhances scanning speed.
- The architecture offers superior dynamic performance and sample handling.
- This technology advances the potential for real-time nanoscale observations and material analysis.
More Related Videos
08:31Probing Surface Electrochemical Activity of Nanomaterials using a Hybrid Atomic Force Microscope-Scanning Electrochemical Microscope AFM-SECM
Published on: February 10, 2021
09:27Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells
Published on: April 2, 2021
Related Concept Videos
Drag Force and Terminal Speed
Atomic Force Microscopy
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
Atomic Orbitals
Intermolecular Forces
Atomic Mass
The Atomic Theory of Matter