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Surgical Management of Multiple Endocrine Neoplasia 1 and Multiple Endocrine Neoplasia 2

Colleen M Kiernan1, Elizabeth G Grubbs1

  • 1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, FCT 17.6000, Houston, TX 77030, USA.

The Surgical Clinics of North America
|July 1, 2019
PubMed

Insights

This article details surgical strategies for managing tumors in multiple endocrine neoplasia 1 (MEN1) and multiple endocrine neoplasia 2 (MEN2). It covers planning, surgical extent, intraoperative care, and recurrent disease management for these rare genetic conditions.

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Genetics

Background:

  • Multiple Endocrine Neoplasia (MEN) syndromes are rare genetic disorders.
  • MEN type 1 (MEN1) and MEN type 2 (MEN2) involve tumors in endocrine glands.
  • Surgical intervention is a cornerstone of management for MEN-associated tumors.

Purpose of the Study:

  • To provide a comprehensive overview of surgical management for MEN1 and MEN2 tumors.
  • To outline optimal preoperative planning, surgical goals, and extent.
  • To discuss intraoperative considerations and the management of recurrent disease.

Main Methods:

  • Review of surgical literature and clinical guidelines for MEN1 and MEN2.
  • Synthesis of information on preoperative assessment and surgical techniques.
  • Analysis of strategies for managing tumor recurrence.

Main Results:

  • Preoperative planning is crucial for successful surgical outcomes in MEN syndromes.
  • The extent of surgery is tailored to specific tumor types and genetic profiles.
  • Effective intraoperative management and surveillance for recurrence are vital.

Conclusions:

  • Multidisciplinary surgical management is essential for patients with MEN1 and MEN2.
  • Adherence to established surgical principles maximizes patient benefit and minimizes complications.
  • Ongoing research is needed to further refine surgical approaches for MEN-associated tumors.
Keywords:
Medullary thyroid carcinomaMultiple endocrine neoplasia type 1Multiple endocrine neoplasia type 2PancreasParathyroidPheochromocytomaSurgical management

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