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Updated: Jan 22, 2026
08:50
Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
Published on: September 2, 2015
9.5K
Basic concepts, current evidence, and future potential for gene therapy in managing cutaneous wounds
Ahmad Oryan1, Esmat Alemzadeh2, Mohammad Zarei3
1Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. oryan@shirazu.ac.ir.
Biotechnology Letters
|July 1, 2019
Summary
Gene therapy enhances wound healing by delivering therapeutic genes via viral or non-viral vectors. Combining gene therapy with stem cells shows promise for skin regeneration.
Area of Science:
- Regenerative Medicine
- Molecular Biology
- Biotechnology
Background:
- Gene therapy is being explored for its potential to accelerate and improve the wound healing process.
- Effective delivery of therapeutic genes to the wound site is crucial for successful gene therapy applications.
Purpose of the Study:
- To review and explain various gene delivery systems used in wound healing.
- To highlight the efficacy of different gene delivery methods and their impact on cutaneous wound regeneration.
Main Methods:
- Comprehensive review of 92 studies on gene therapy for wound healing.
- Description of viral vectors (adenoviruses, AAVs, retroviruses) and non-viral vectors (naked DNA, liposomes, gene gun, electroporation, nanoparticles).
Main Results:
- Viral transfection, liposomal vectors, and electroporation are key gene delivery systems.
- Genes encoding growth factors or cytokines improve wound closure compared to synthetic factors.
- Combination of stem cell and gene therapy is effective for cutaneous wound regeneration.
Conclusions:
- Gene therapy offers promising methods for wound repair.
- Further clinical investigations are needed to fully understand gene delivery technologies in wound healing.
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