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Updated: Jan 22, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
Published on: January 24, 2013
Genetics of Circadian Rhythms
Martha Hotz Vitaterna1, Kazuhiro Shimomura2, Peng Jiang1
1Center for Sleep and Circadian Biology; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.
Abstract:
In mammals, genetic influences of circadian rhythms occur at many levels. A set of core "clock genes" have been identified that form a feedback loop of gene transcription and translation. The core genetic clockwork generates circadian rhythms in cells throughout the body. Polymorphisms in both core clock genes and interacting genes contribute to individual differences in the expression and properties of circadian rhythms. The circadian clock profoundly influences the patterns of gene expression and cellular functions, providing a mechanistic basis for the impact of the genetic circadian system on normal physiological processes as well as the development of diseases.
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