Circadian Rhythm Sleep-Wake Phase Disorders
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Updated: Jan 22, 2026

Assaying Locomotor Activity to Study Circadian Rhythms and Sleep Parameters in Drosophila
Published on: September 28, 2010
Elizabeth Culnan1, Lindsay M McCullough2, James K Wyatt3
1Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612-3833, USA.
Abstract:
This article reviews delayed and advanced sleep-wake phase disorders. Diagnostic procedures include a clinical interview to verify the misalignment of the major nocturnal sleep episode relative to the desired and social-normed timing of sleep, a 3-month or greater duration of the sleep-wake disturbance, and at least a week of sleep diary data consistent with the sleep timing complaint. Treatment options include gradual, daily shifting of the sleep schedule (chronotherapy); shifting circadian phase with properly timed light exposure (phototherapy); or melatonin administration. Future directions are discussed to conclude the article.
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