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Circadian Rhythms: Implications for Health and Disease
Sabra M Abbott1, Phyllis C Zee2
1Department of Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Abbott Hall 524, Chicago, IL 60611, USA.
Neurologic Clinics
|July 2, 2019
Summary
Properly synchronized circadian rhythms are vital for health. Disruptions are linked to cardiometabolic and neurologic diseases, but circadian interventions show promise for improving health.
Area of Science:
- Chronobiology
- Human Physiology
- Disease Pathogenesis
Background:
- Circadian rhythms are endogenous biological processes influencing nearly all organisms.
- These internal biological clocks are present throughout the human body.
- Coordination of circadian rhythms with internal and external cues is crucial for health.
Purpose of the Study:
- To review data associating circadian dysregulation with disease risk.
- To explore the link between circadian rhythm disruption and cardiometabolic, neurologic, and neurodegenerative diseases.
- To discuss emerging evidence for circadian-based health interventions.
Main Methods:
- Literature review of existing scientific data.
- Analysis of studies on circadian rhythm disruption and disease.
- Examination of research on the efficacy of circadian interventions.
Main Results:
- Circadian dysregulation is associated with increased risk of cardiometabolic diseases.
- Evidence links disrupted circadian rhythms to neurologic and neurodegenerative conditions.
- Limited but growing data supports the health benefits of circadian interventions.
Conclusions:
- Maintaining synchronized circadian rhythms is essential for preventing disease.
- Circadian dysregulation poses a significant risk factor for major health conditions.
- Circadian-based strategies represent a promising avenue for health improvement.
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