[Fibrinogen-fibrin degradation products in diabetes mellitus]

The fibrin split products, soluble fibrin monomer complexes and other coagulation indices were studied in 38 diabetic patients. In these patients there is a tendency towards hypercoagulation. The patients with retinopathy show higher values of fibrin split products and soluble fibrin monomer complexes than the patients without retinopathy. In 24 diabetic patients with ketoacidosis the follow up showed significant increase of the indices studied and correlation of fibrin split products with blood pH. In patients with severe ketoacidosis and diabetic coma disseminated intravasal coagulopathy was found. The early prophylactic treatment of these complications with antiaggregants and anticoagulants is discussed and recommended.