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[Verification of Relationship between Administration of Linezolid and Vomiting]

Takezo Tsutsumi1, Shungo Imai1, Katsuhisa Yamada2

  • 1Department of Pharmacy, Hokkaido University Hospital.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|July 2, 2019
PubMed

Insights

Linezolid (LZD) antibiotic use was linked to a higher incidence of vomiting in orthopedic patients. Potential risk factors include female gender, older age, renal impairment, and concurrent rifampicin use.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Orthopedic Surgery

Background:

  • Linezolid (LZD) is an effective antibiotic for methicillin-resistant Staphylococcus aureus infections, including bone and joint infections.
  • Nausea and vomiting are potential side effects of LZD, but incidence rates and risk factors are not well-documented.

Purpose of the Study:

  • To investigate the relationship between Linezolid administration and the occurrence of vomiting.
  • To identify risk factors associated with LZD-induced vomiting in orthopedic patients.

Main Methods:

  • Retrospective study comparing vomiting rates in patients receiving LZD versus other antibiotics.
  • Univariate logistic regression analysis to identify risk factors for vomiting.

Main Results:

  • Vomiting occurred significantly more often in the LZD group (23.4%) compared to the non-LZD group (7.5%).
  • Identified risk factors for vomiting included LZD administration, female gender, age ≥65 years, renal impairment, and concomitant rifampicin use.

Conclusions:

  • Linezolid administration is associated with an increased risk of vomiting in orthopedic patients.
  • Factors such as female gender, advanced age, renal impairment, and concurrent rifampicin use may further increase this risk.
Keywords:
adverse drug reactionlinezolidvomiting

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