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Published on: April 10, 2020
Cascade cyclization and acyl migration of propargylic esters with isocyanides: rapid access to substituted furans
Jie Hu1, Youwen Fei1, Hongbin Zhao1
1Department of Chemistry, Center for Supramolecular Chemistry and Catalysis, College of Sciences & Institute for Sustainable Energy, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China. hongbinzhao@shu.edu.cn lijian@shu.edu.cn.
Abstract:
A novel rearrangement of ester-activated propargylic acetate with isocyanide has been disclosed. This protocol enables a quick synthesis of polysubstituted furan derivatives. The reaction outcome also reveals that the ester group is employed for the construction of a furan ring and an acyl migration is observed.
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