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Cyclosporine in the treatment of red cell aplasia
D L Williams1, A S Mageed, H Findley
1Department of Pediatrics, Emory University, Atlanta, Georgia 30322.
The American Journal of Pediatric Hematology/Oncology
|January 1, 1987
Abstract:
A 4-year-old girl was diagnosed to have pure red cell aplasia. For 5 years, she received multiple packed red cell transfusions (average 11/year). Several therapeutic maneuvers were attempted including prednisone, oxymethalone, plasmaphoresis, high dose methyl prednisolone-to no avail. Finally, cyclosporine was administered for 5 months. This increased her reticulocyte count and cured the disease. For the last 2 years she has been in excellent health and has not required any further transfusions. The possible mechanism of action of cyclosporine in this disease is discussed.