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Updated: Jan 22, 2026

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
Published on: November 1, 2014
Species Specificity on Interaction between IgE and FcεRI
Xiangsheng Li1,2, Nannan Wang1,2, Yang Zhao1,2
1College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
Abstract:
Allergic diseases are one of the most prevalent diseases at present, it is imperative to understanding the pathophysiology and treatment strategies for allergic diseases. In this process, the binding of IgE and FcεRI on effector cells plays a critical role in triggering allergic reactions. However, the species specificity of the interaction between IgE and FcεRI has not been clearly explained. This review described the characteristics and the interaction mechanism in the allergic reaction of IgE and FcεRI and summarized the species specificity between IgE and FcεRI.
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