NINJ2 Gene Polymorphisms and Susceptibility to Ischemic Stroke: An Updated Meta-Analysis
Fangfang Nie1, Mingli Yu2, Mengwei Liu1
1Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China.
Current Neurovascular Research
|July 2, 2019
Summary
The nerve injury-induced protein 2 (NINJ2) gene polymorphism rs12425791 is associated with an increased risk of ischemic stroke (IS). However, the NINJ2 gene polymorphism rs11833579 shows no association with IS risk.
Area of Science:
- Genetics
- Neurology
- Epidemiology
Background:
- Ischemic stroke (IS) is a major global health concern.
- Genome-wide association studies (GWAS) have suggested a link between NINJ2 gene polymorphisms (rs11833579 and rs12425791) and IS susceptibility.
- Conflicting results from previous studies necessitate further investigation.
Conclusions:
- The NINJ2 gene polymorphism rs12425791 is identified as a susceptible factor for ischemic stroke.
- The NINJ2 gene polymorphism rs11833579 is not associated with IS risk.
- Further large-scale studies are recommended to confirm the association between the NINJ2 gene and IS.
Related Concept Videos
01:09Directing Effect of Substituents: meta-Directing Groups
5.8K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.8K
01:31Magnetic Susceptibility and Permeability
2.3K
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
2.3K
01:05Single Nucleotide Polymorphisms-SNPs
18.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.0K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
682
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
682
01:26Susceptibility, Permittivity and Dielectric Constant
2.8K
When placed in an external electric field, a dielectric material gets polarized. The charge density in the dielectric material is given by the sum of the bound and free charge densities, while the total charge density can also be written in terms of the total electric field. The bound charge density can be measured in terms of polarization, leading to the relationship between electric displacement and polarization.
2.8K
01:27Regulation of Stroke Volume
4.8K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.8K