Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Flecainide distribution in human tissues.

R Latini¹, A Cavalli, A P Maggioni

¹Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

British Journal of Clinical Pharmacology

|December 1, 1987

Summary

This summary is machine-generated.

This study tracked flecainide distribution in human tissues after chronic use. Lungs had the highest concentration, while adipose tissue had the lowest, offering insights into antiarrhythmic drug action.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies.

European journal of medicinal chemistry·2025

Same author

Dynamical features of smooth muscle actin pathological mutants: The arginine-257(258)-Cysteine cases.

Computational and structural biotechnology journal·2025

Same author

Characteristics and outcomes in patients with a prior myocardial infarction treated with extended dual antiplatelet therapy with ticagrelor 60 mg: findings from ALETHEIA, a multi-country observational study.

European heart journal. Cardiovascular pharmacotherapy·2023

Same author

Regularized Bennett and Zwanzig free energy estimators.

The Journal of chemical physics·2023

Same author

Optimal Transport for Free Energy Estimation.

The journal of physical chemistry letters·2023

Same author

Modified haemagglutination inhibition assay for the detection of canine parvovirus type 2 antibodies in dog sera.

Veterinary journal (London, England : 1997)·2021

Same journal

N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.

British journal of clinical pharmacology·2026

Same journal

Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

British journal of clinical pharmacology·2026

Same journal

Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.

British journal of clinical pharmacology·2026

Same journal

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.

British journal of clinical pharmacology·2026

Same journal

Relationship between continuous infusion meropenem PK/PD target attainment and C-reactive protein dynamics in onco-haematologic patients with febrile neutropenia.

British journal of clinical pharmacology·2026

Same journal

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

British journal of clinical pharmacology·2026

See all related articles

Area of Science:

Pharmacology
Toxicology
Human Physiology

Background:

Understanding drug distribution in human tissues is crucial for evaluating therapeutic efficacy and potential side effects of antiarrhythmic medications.
Flecainide is a commonly prescribed antiarrhythmic drug, but its precise tissue distribution patterns require further elucidation.