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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
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Targeting the Tumor Microenvironment in Renal Cell Cancer Biology and Therapy

Isabel Heidegger1, Andreas Pircher2, Renate Pichler1

  • 1Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.

Frontiers in Oncology
|July 2, 2019
PubMed

Insights

Renal cell cancer (RCC) treatments face resistance from the tumor microenvironment (TME). Understanding and targeting TME components can improve anti-angiogenic and immunotherapy effectiveness in RCC.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • Renal cell cancer (RCC) is a vascularized and immunogenic malignancy.
  • Anti-angiogenic and immunotherapies have transformed RCC treatment.
  • Therapy resistance is a significant challenge, often driven by the tumor microenvironment (TME).

Purpose of the Study:

  • To review the components of the RCC TME.
  • To discuss the TME's role in disease progression and treatment resistance.
  • To explore strategies for modulating the TME to enhance therapeutic outcomes.

Main Methods:

  • Literature review of preclinical and clinical findings.
  • Analysis of TME components and their impact on therapy.
  • Discussion of combined therapeutic strategies and novel targets.

Main Results:

  • The RCC TME is dynamic, adaptive, and heterogeneous, contributing to resistance.
  • Modulating TME components offers potential to overcome resistance to anti-angiogenic and immunotherapies.
  • Combinational targeting, including anti-angiogenic agents and immune checkpoint inhibitors, shows promise.

Conclusions:

  • The TME plays a critical role in RCC progression and treatment response.
  • Targeting the TME is essential for overcoming resistance and improving patient outcomes.
  • Further research into novel TME-targeting strategies is warranted.
Keywords:
anti-angiogenesiscombination therapyimmunotherapyrenal cell cancertherapytumor microenvironment (TME)

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