Cerebral Gray and White Matter Involvement in Anorexia Nervosa Evaluated by T1, T2, and T2* Mapping

Changes in the brain composition of anorexics could potentially be expected, opening the door to new imaging approaches where quantitative and qualitative MRI have a role. Our purpose was to investigate anorexia-related brain dehydration and myelin depletion by analyzing T1, T2, and T2* relaxation times of different brain structures in anorexics and controls.

Thirty-eight anorexic female patients (mean age, 26.2 years; age range, 16.2-48.7 years; mean BMI, 14.5 kg/m² ; BMI range, 10.0-18.4 kg/m² ) underwent brain MRI between August 2014 and August 2018. Controls were 16 healthy females (mean age, 28.0 years; age range, 22.3-34.7 years; mean BMI, 20.9 kg/m² ; BMI range, 18.4-26.6 kg/m² ). T1, T2, and T2* relaxation times were obtained for different brain structures in anorexics and controls as part of this retrospective case-control study.

The T1 relaxation times of gray and white matter were significantly lower in anorexics (P = .009), whereas the T2 relaxation times of gray matter were higher (P < .001). There were no statistically significant differences in gray matter T2* relaxation times or in white matter T2 and T2* relaxation times between anorexics and controls. Occipital lobe gray matter showed the shortest T1, T2, and T2* relaxation times of all brain regions (P < .05).

T1 shortening in anorexics suggests both dehydration and myelin loss, whereas T2 prolongation points toward myelin loss (myelin water has lower T2), which seems to be less discernible in white matter. Shorter overall relaxation times in the most posterior regions of the brain suggest higher iron content.