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Prevention of Bronchopulmonary Dysplasia: A Summary of Evidence-Based Strategies

Erik A Jensen1

  • 1Division of Neonatology and Department of Pediatrics; Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.

Neoreviews
|July 2, 2019
PubMed

Insights

Bronchopulmonary dysplasia (BPD) remains a significant risk for extremely preterm infants, with rates stagnant for decades. Effective prevention requires multiple evidence-based strategies, as no single intervention suffices.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Perinatal Research

Background:

  • Bronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infants born extremely preterm.
  • While less common in larger infants, BPD rates in extremely preterm infants have not improved and may be rising.
  • Current therapeutic interventions lack singular efficacy in preventing BPD.

Purpose of the Study:

  • To review current evidence-based strategies for the prevention of bronchopulmonary dysplasia (BPD).
  • To focus on prevention methods supported by data from randomized controlled trials (RCTs).

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) focusing on BPD prevention.
  • Analysis of evidence-based therapeutic interventions for extremely preterm infants.

Main Results:

  • No single intervention has proven effective in preventing BPD.
  • A multifaceted approach utilizing multiple evidence-based strategies is necessary.
  • Data primarily derived from RCTs guides current prevention recommendations.

Conclusions:

  • Preventing BPD in extremely preterm infants requires a comprehensive strategy.
  • Clinicians must implement a combination of evidence-based interventions.
  • Continued research and adherence to trial data are crucial for improving outcomes.

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