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Evaluation of Extracellular Vesicle Function During Malaria Infection
Published on: February 14, 2018
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New insights into extracellular vesicle biogenesis and function
Arash Latifkar1, Yun Ha Hur2, Julio C Sanchez2
1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Journal of Cell Science
|July 3, 2019
Summary
Most cells release extracellular vesicles (EVs) for communication. This review covers how microvesicles (MVs) and exosomes form and impact cancer progression and stem cell biology.
Area of Science:
- Cell Biology
- Biochemistry
- Oncology
Background:
- Cells communicate using extracellular vesicles (EVs), including microvesicles (MVs) and exosomes.
- EVs contain proteins, RNA, and DNA, influencing recipient cell activities.
- EV biogenesis is often dysregulated in pathologies like cancer, promoting tumor progression.
Purpose of the Study:
- To review recent advances in understanding EV formation and release mechanisms.
- To emphasize the role of EVs in cancer progression and stem cell biology.
Main Methods:
- Literature review of current research on extracellular vesicle biogenesis.
- Focus on mechanisms of microvesicle and exosome formation and release.
- Analysis of EV involvement in cancer and stem cell biology.
Main Results:
- Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, are key mediators of intercellular communication.
- EVs carry diverse molecular cargo (proteins, RNA, DNA) that can alter recipient cell functions.
- Dysregulated EV biogenesis is implicated in cancer, potentially driving tumor growth, resistance, invasion, and metastasis.
Conclusions:
- Extracellular vesicles play a significant role in intercellular communication and biological responses.
- Understanding EV biogenesis mechanisms is crucial for comprehending their impact on cancer and stem cell biology.
- Further research into EVs offers potential therapeutic strategies for cancer and other diseases.
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