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Detection of Exosomal Biomarker by Electric Field-induced Release and Measurement EFIRM
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Exosomal long non-coding RNAs as biomarkers in human diseases
Evelyn Kelemen1, Judit Danis1,2, Anikó Göblös1,2
1Department of Dermatology and Allergology, Research Institute of Translational Biomedicine, University of Szeged, Hungary.
EJIFCC
|July 3, 2019
Summary
Disease biomarkers can be found in extracellular vesicles, specifically long non-coding RNAs (lncRNAs) within exosomes. These circulating exosomal lncRNAs show promise for developing highly specific and sensitive diagnostic tools for various diseases.
Area of Science:
- Biochemistry
- Molecular Biology
- Biomarker Research
Background:
- Extracellular vesicles (EVs), including exosomes, are released by cells and found in body fluids.
- EVs contain molecules like proteins and nucleic acids that can reflect disease states.
- Long non-coding RNAs (lncRNAs) are found within EVs and are specific to cell type and disease.
Purpose of the Study:
- To summarize current knowledge on disease-associated exosomal long non-coding RNAs (lncRNAs).
- To highlight the potential of exosomal lncRNAs as biomarkers for disease diagnosis.
Main Methods:
- Literature review of studies on extracellular vesicles and long non-coding RNAs.
- Analysis of research on exosomal content and its relation to disease states.
Main Results:
- Exosomal lncRNAs are specific to their cell of origin and disease state.
- Circulating exosomal lncRNAs are emerging as promising disease biomarkers.
- Combinations of exosomal markers may offer highly sensitive and specific diagnostic potential.
Conclusions:
- Exosomal lncRNAs represent a significant area for biomarker research.
- Further functional studies on exosomes and lncRNAs are needed for diagnostic development.
- Exosomal lncRNAs hold potential for sensitive and specific disease detection.
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