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Catatonic Schizophrenia: Cases with Possible Genetic Predisposition.
Maryam Tariq1, Muhammad Iqbal Afridi2, Dua Saleem3
1Psychiatry and Behavioral Sciences, Jinnah Postgraduate Medical Center, Karachi, PAK.
Cureus
|July 3, 2019
Summary
This study presents two brothers diagnosed with catatonic schizophrenia, highlighting potential genetic factors and treatment responses. Lorazepam and olanzapine showed efficacy, with olanzapine being more effective than aripiprazole.
Area of Science:
- Psychiatry
- Neuroscience
Background:
- Catatonic schizophrenia is a severe subtype characterized by catatonia, often associated with poor prognosis due to negative symptoms and early onset.
- This case study explores catatonic schizophrenia in two brothers without a known genetic predisposition, suggesting environmental or subtle genetic influences.
Observation:
- Two brothers presented with identical symptoms of catatonic schizophrenia, including mutism, psychomotor retardation, refusal to eat/drink, and lack of self-care.
- Patient A (18) received aripiprazole and lorazepam, showing gradual improvement. Patient B (30) received olanzapine and lorazepam, exhibiting a faster response.
Findings:
- Both patients responded to lorazepam, with subsequent treatment showing differential efficacy.
- Olanzapine appeared more efficacious than aripiprazole in treating catatonic schizophrenia in these cases.
Implications:
- The case suggests a potential genetic predisposition or shared environmental factors contributing to catatonic schizophrenia in siblings.
- Early intervention with appropriate antipsychotics and benzodiazepines is crucial for managing catatonic schizophrenia, with olanzapine showing promise.
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