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How Ocular Surface Microbiota Debuts in Type 2 Diabetes Mellitus
Siqi Li1, Guoguo Yi1, Hui Peng2
1Department of Ophthalmology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Frontiers in Cellular and Infection Microbiology
|July 3, 2019
Summary
Type 2 diabetes mellitus (T2DM) alters ocular surface bacterial communities, increasing microbial diversity and specific bacterial genera like Acinetobacter and Pseudomonas. These changes correlate with ocular discomfort in T2DM patients.
Area of Science:
- Microbiology
- Ophthalmology
- Endocrinology
Background:
- High glucose levels in type 2 diabetes mellitus (T2DM) promote bacterial growth on the ocular surface (OS).
- This can impact the conjunctival bacterial community and potentially lead to ocular surface disease.
Purpose of the Study:
- To investigate and compare the OS bacterial flora in T2DM patients and healthy controls.
- To identify specific bacterial taxa associated with T2DM and ocular surface conditions.
Main Methods:
- 16S rRNA sequencing was used for bacterial identification in the ocular surface microbiota.
- 54 eyes from 31 T2DM patients and 23 healthy subjects were analyzed.
- Factors influencing microbial growth were controlled.
Main Results:
- OS microbiota diversity was higher in the T2DM group compared to controls.
- T2DM patients showed lower abundance of Proteobacteria and higher abundance of Bacteroidetes at the phylum level.
- Significantly increased abundance of Acinetobacter and Pseudomonas genera was observed in T2DM patients.
Conclusions:
- The OS flora in T2DM patients is significantly different from healthy individuals.
- Alterations in OS microbiota are associated with Ocular Surface Disease Index and T2DM duration.
- These microbial shifts may contribute to ocular discomfort in T2DM.
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