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Inflammation: predictive factor for negative evolution of prostate diseases.

Adrian Silviu Crişan1, Imola Miklos, Alin Ioan Greluş

  • 1Department of Surgery, Faculty of Medicine, "Vasile Goldiş" Western University of Arad, General Surgery Unit, Emergency County Hospital, Arad, Romania; carmen.neamtu@gmail.com, totolici_bogdan@yahoo.com.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|July 3, 2019
PubMed
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Inflammation significantly impacts prostate disease progression. Higher inflammation correlates with more aggressive prostate cancer (PCa) and severe symptoms in benign prostate conditions.

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Prostate diseases like prostatitis, benign prostate hypertrophy, and prostate cancer (PCa) are common, with prevalence varying by age.
  • Understanding the factors driving disease progression is crucial for effective patient management.

Purpose of the Study:

  • To investigate the role of inflammation in the progression of both benign and malignant prostate diseases.
  • To correlate inflammation levels with disease severity and aggressiveness.

Main Methods:

  • Clinical and paraclinical diagnostic techniques including serum prostate-specific antigen (PSA) levels, transrectal ultrasound, and prostate biopsy/transurethral resection.
  • Histopathological and immunohistochemical analysis of prostate tissue specimens.

Main Results:

  • Elevated inflammation rates in prostate cancer (PCa) patients were associated with higher Gleason scores in both castration-sensitive and castration-resistant groups.
  • A strong correlation was observed between high inflammation grades and increased International Prostate Symptom Score (IPSS) values.

Conclusions:

  • Inflammation plays a significant role in the evolution of benign and malignant prostate diseases.
  • Inflammation directly influences symptom severity and disease aggressiveness, including prostate cancer.