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Model-based analysis on systemic availability of co-administered cannabinoids after controlled vaporised
Zheng Liu1,2,3, Peter Galettis1,4, Samantha J Broyd5
1Schools of Medicine and Public Health, University of Newcastle, Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Internal Medicine Journal
|July 3, 2019
Summary
High-dose cannabidiol (CBD) significantly reduced the systemic availability of Δ9 -tetrahydrocannabinol (THC) when co-administered via vaporization. Frequent cannabis users showed higher systemic availability of both THC and CBD.
Area of Science:
- Pharmacology and Pharmacokinetics
- Cannabinoid Research
- Drug Delivery Systems
Background:
- Δ9 -tetrahydrocannabinol (THC) and cannabidiol (CBD) are key medicinal cannabinoids.
- Vaporized administration offers superior systemic availability, reduced variability, and faster delivery of cannabinoids.
- The impact of co-administered CBD on THC pharmacokinetics, particularly systemic availability after vaporization, remains largely unknown.
Purpose of the Study:
- To determine how different doses of co-administered CBD affect the systemic availability of vaporized THC.
- To compare the systemic availability of THC and CBD in frequent versus infrequent cannabis users.
Main Methods:
- Employed a randomized, double-blind, crossover, placebo-controlled study design.
- THC and/or CBD in ethanol were administered via vaporization and inhalation.
- Plasma concentrations of THC and CBD were analyzed, with data pooled for THC pharmacokinetic modeling.
Main Results:
- Population pharmacokinetic models for THC and CBD were successfully developed.
- Concomitant inhalation of high-dose CBD significantly decreased the systemic availability of THC.
- Frequent cannabis users demonstrated higher systemic availability of both THC and CBD when high-dose CBD was administered.
Conclusions:
- Findings provide valuable insights for future pharmacokinetic studies of medicinal cannabinoids.
- Results can inform the development of practical dosing guidelines for medical cannabis use.
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