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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.0K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

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The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
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Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

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The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

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Lung Cancer Genomics.

Ankur R Parikh1

  • 1Cancer Treatment Centers of America, Philadelphia, PA, USA. ankur.parikh@ctca-hope.com.

Acta Medica Academica
|July 3, 2019
PubMed
Summary
This summary is machine-generated.

Genomic testing identifies mutations in lung cancer, guiding personalized treatment for better outcomes. Clinicians must offer this precision medicine approach, especially for advanced lung cancer patients.

Keywords:
GenomicsImmunotherapyLung CancerNext-Generation SequencingTargeted Therapy

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Area of Science:

  • Oncology
  • Genetics
  • Precision Medicine

Background:

  • Lung cancer treatment is evolving due to tumor heterogeneity.
  • Genomic testing identifies specific mutations and resistance markers.
  • Advanced lung cancer has a poor prognosis, necessitating novel treatment strategies.

Purpose of the Study:

  • To highlight the importance of genomic testing in lung cancer.
  • To discuss the application of genomic profiling for treatment selection.
  • To emphasize the role of genomic testing in precision medicine for lung cancer.

Main Methods:

  • Genomic profiling of lung tumors.
  • Identification of targetable mutations and resistance mechanisms.
  • Review of evidence supporting genomic testing in clinical guidelines.

Main Results:

  • Genomic testing is now part of national lung cancer treatment guidelines.
  • Test results can predict response to specific therapies.
  • Genomic profiling offers improved outcomes for advanced lung cancer.

Conclusions:

  • Clinicians must be familiar with genomic testing for lung cancer patients.
  • Genomic testing is crucial for personalized treatment in the current era of precision medicine.
  • Offering genomic testing, particularly for advanced lung cancer, is imperative.