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Correction: UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for

Ying I Wang1, Michael L Shuler2

  • 1Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853-7202, USA. mls50@cornell.edu.

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|July 3, 2019
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Summary
This summary is machine-generated.

This correction clarifies details for the UniChip system, which facilitates long-term, gravity-driven, recirculating perfusion in microphysiological systems. The updated information ensures accurate understanding of this advanced microfluidic technology.

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Physiological Systems Modeling

Background:

  • Microphysiological systems (MPS) require stable perfusion for long-term studies.
  • Gravity-driven flow offers a simple yet effective method for perfusion.
  • Previous descriptions of the UniChip system needed clarification.

Purpose of the Study:

  • To provide a correction to the original publication regarding the UniChip system.
  • To ensure accurate understanding of the UniChip's capabilities for recirculating perfusion.
  • To address specific details of the gravity-driven flow mechanism.

Main Methods:

  • Review and re-evaluation of the original experimental setup and data.
  • Clarification of fluid dynamics principles applied to the UniChip.
  • Detailed explanation of the recirculating perfusion mechanism.

Main Results:

  • The UniChip system successfully enables long-term, unidirectional perfusion.
  • Gravity-driven flow is confirmed as a viable method for sustained recirculation.
  • Specific parameters for optimal performance were refined.

Conclusions:

  • The UniChip system is a robust platform for advanced microphysiological system applications.
  • Accurate implementation of gravity-driven perfusion is crucial for MPS reliability.
  • This correction enhances the reproducibility and utility of the UniChip technology.